Endocrine Abstracts

We report a case of multisystem Langerhans cell histiocytosis (LCH) with pituitary involvement nearly 20 years after initial presentation. LCH is a rare disorder in which granulomatous deposits occur at multiple sites within the body often involving the hypothalamo-pituitary axis.A 48-year-old gentleman had Histiocytosis X initially involving groin in1987, responding poorly to treatment with topical nitrogen mustard and radiotherapy. Involvement of exter...

Aim: Audit the management of patients with thyrotoxicosis in the thyroid clinic at a District General Hospital, focusing on treatment methods and long term follow up.Method: Prospective data collected from randomly selected 50 case notes and laboratory results over 4 months. Titration dose with Carbimazole or Propylthiouracil with close monitoring of thyroid function test is the treatment method followed.Results: Eighty-six percent...

Aims: Testosterone treatment is controversial as long-term outcome data are not available; however prescriptions for testosterone are becoming more common.We looked at the symptoms on presentation, indications for testosterone replacement, forms of testosterone replacement, and adherence to present guidelines for monitoring.Methods: Data was collected from case notes of 47 patients on testosterone replacement attending endocrine cl...

Case report: A 52-year-old woman presented with an 11-month history of increasing hirsutism and deepening voice. She had a past history of total abdominal hysterectomy (ovaries preserved) with adjuvant chemotherapy and radiotherapy for cervical carcinoma. She was on no medication. Examination revealed evidence of virilisation with no other abnormality.Investigations: Total testosterone=10.7 nmol/l (<2.9).FSH=31.7 U/l (37–1...

Background: Hypothyroidism is reported to be associated with mild insulin resistance though severe insulin resistance is rare. We report the case of a man presented with reversible severe insulin resistance in hypothyroidism.Case report: A 23-year-old obese man with autism was presented with poor responsiveness (GCS 7/15). He had general malaise for 2 days prior to admission. On admission, his test results showed random glucose – 60.8 mmol/l, potass...